Gaming: Latest How To Use The Severed Hand In Resident Evil Requiem 2026

Here's what the mysterious appendage actually does.

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The Severed Hand is a bit of a mystery in Resident Evil Requiem. After you escape the basement, you can pick this item up off the floor in front of the elevator where it was sliced from The Girl when the lift dropped. You're likely wondering what the hell you're supposed to do with it, since its description merely states that "It's still a little warm". Gross.

You've likely examined it all over, too. Well, the good news is it does have a function, though this creates another mystery versus resolving anything. So, I'll explain how to use the Severed Hand.

Now, before we start, it's important to note that you only have a brief window with which to use the Severed Hand while playing as Grace. After you return from the basement, you can leave the Care Center by unlocking the door with indents, since you've solved all three puzzles boxes now. You'll have to use the hand before that. You can take the Severed Hand to a Laser Microscope, like the ones you use to analyse samples and unlock crafting recipes.

There's one in the Blood Lab in the East Wing, or another in the Office on the second floor of the West Wing. You can solve the little atom minigame to analyse it by selecting:

Now, doing so won't give you a crafting diagram, but it will give you a message. I won't spoil this, but the message also includes a code:

After looking into this, this code is apparently an amino acid chain like in DNA, namely:

Now, you might be wondering what any of this means. Turns out, it's all part of the incredibly complicated The Final Puzzle challenge you can see in the challenge menu. This puzzle has a lot of very elaborate steps, and, as of writing this, no one has worked it out yet. I'll update this guide when a solution is found, so make sure to keep a decent variety of save points across the game so you can return if needed.

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Source: PC Gamer